Favorable wound healing has always been a major quest in dental and medical surgery. It is a concern in healthy as well as compromised patients. To improve and accelerate healing of both hard and soft tissue, substitutes including growth factors, biomaterials, and membranes have been traditionally used. Recent research clearly indicates that Leukocyte- and Platelet-Rich Fibrin (L-PRF®) significantly enhances wound healing in both soft and hard tissue. Evidence now supports the assertion that this has the potential to replace the above-mentioned substitutes in many situations. The greatest strength of any new therapy or technique lies in four fundamental pillars: availability, affordability, accessibility, and reproducibility. The Natural Guided Regeneration therapy, based on L-PRF, has surpassed the test of these four pillars.